Regions defined based on landform characteristics are called "physiographic" or "geomorphic" regions. Physiography involves the delineation and description of regions from the viewpoint of geomorphology. Geologist Nevin Fenneman defined a classic three-level hierarchical system of physiographic regions for the United States in 1946. The regions are called divisions, provinces, and sections. For example, there are 8 large physiographic divisions, such as the Canadian Shield and the Interior Plains. These are subdivioned into provinces and sectiones. The appalachiane Highlands division, for example, contains the Valley and Ridge province, which in turn contains three sections, the Tennessee section, Middle section, and Hudson section. The Valley and Ridge province approximately corresponds to the more general region known as the Ridge-and-valley Appalachians.

The field of historical geography involves the study of human history as it relates to places and regions, or, inversely, the study of how places and regions have changed over time.

In describing historic regions of America, Meinig writes of "The Great Fishery" off the coast of Newfoundland and New England, an oceanic region that includes the Grand Banks. He rejects regions traditionally used in describing American history, like New France, "West Indies", the Middle Colonies, and the individual colonies themselves (Province of Maryland, for example). Instead he writes of "discrete colonization areas", which may be named after colonies, but rarely adhere strictly to political boundaries. Historic regions of this type Meinig writes about include "Greater New England" and its major sub-regions of "Plymouth", "New Haven shores" (including parts of Long Island), "Rhode Island" (or "Narragansett Bay"), "the Piscataqua", "Massachusetts Bay", "Connecticut Valley", and to a lesser degree, regions in the sphere of influence of Greater New England, "Acadia" (Nova Scotia), "Newfoundland and The Fishery/The Banks".

A tourism region is a geographical region that has been designated by a governmental organization or tourism bureau as having common cultural or environmental characteristics. These regions are often named after a geographical, former, or current administrative region or may have a name created for tourism purposes. The names often evoke certain positive qualities of the area and suggest a coherent tourism experience to visitors. Countries, states, provinces, and other administrative regions are often carved up into tourism regions which, in addition to drawing the attention of potential tourists, often provide tourists who are otherwise unfamiliar with an area with a manageable number of attractive options.

Natural resources often occur in distinct regions. Natural resource regions can be a topic of physical geography or environmental geography, but also have a strong element of human geography and economic geography. A coal region, for example, is a physical or geomorphological region, but its development and exploitation can make it into an economic and a cultural region. Some examples of natural resource regions include the Rumaila Field, the oil field that lies along the border or Iraq and Kuwait and played a role in the Gulf War; the Coal Region of Pennsylvania, which is a historical region as well as a cultural, physical, and natural resource region; the South Wales Coalfield, which like Pennsylvania's coal region is a historical, cultural, and natural region; the Kuznetsk Basin, a similarly important coal mining region in Russia; Kryvbas, the economic and iron ore mining region of Ukraine; and the James Bay Project, a large region of Quebec where one of the largest hydroelectric systems in the world has been developed.

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